An early effort from Ryan Harley and a late strike from Daniel Nardiello helped to secure the local bragging rights for Exeter City in their Johnstone's Paint Trophy clash against Plymouth Argyle.
Chris Clark replied for the Pilgrims, but it was the Grecians who march on to the Semi-Finals in front of a crowd of 9,460.
The win now leaves Paul Tisdale's men within three matches of reaching the final at Wembley.
They are also one game away from equalling their best ever run in the competition of reaching the Southern Area Final, which they achieved in 1993 and 2000.
