Tonight's Johnstone's Paint Trophy Southern Area Quarter Final clash between Plymouth Argyle and Exeter City will be the first time that the two sides have faced each other since February 26th 2002.
Argyle, at the time, were on their way to clinching the Division Three title with a record 102 points and Exeter were later to lose their league status just over a year later.
Since then the Grecians have regained their league status and, following back to back promotions, are now establishing themselves as a League One club. The Pilgrims, on the other hand, were relegated from the Championship last season and have been extremely inconsistent during the current campaign.
It will also be the first time that the respective managers Peter Reid and Paul Tisdale have faced each other.
During his career as a player and as a manager, Reid has experienced derby matches in Merseyside, Manchester and the North East, so his experiences may prove to be beneficial to his players.
Tisdale has enjoyed consecutive promotions with the Grecians and guided them to a league win over Leeds United last season, only a week after the Yorkshire side had knocked Manchester United out of the FA Cup, so he is no stranger to big occasions.
For whoever does come out on top, they will be within three matches of a possible trip to Wembley and will also hold local bragging rights. However, the loser will be even keener for revenge when the two sides meet in the league on December 11th.