This weekend's matches sees Plymouth Argyle, who are still searching for their first home win of the season, take on Sheffield Wednesday at Hillsborough.
Argyle have so far only managed to pick up one point at Home Park so far this season and haven't won in front of their own fans since 16th March 2010, when they recorded a 3-2 victory over Bristol City.
Peter Reid will be sweating on the fitness of skipper Carl Fletcher who missed their 1-1 draw at Colchester United last week with a thigh strain.
The Owls, meanwhile, have lost their last two league encounters after winning three of their opening four League One fixtures of the campaign.
Exeter City will be looking to make it three wins out of three when they play host to League One leaders Peterborough United at St James Park. Manager Paul Tisdale has no new injury worries, but skipper Matt Taylor and Player-Coach Marcus Stewart remain sidelined.
After beating Tranmere Rovers 3-1 last week, Yeovil Town travel to Huddersfield Town as Terry Skiverton's men look to go on a run of wins. His counterpart at the Galpharm Stadium Lee Clark has stated he believes his side will not get a easy ride against the Glovers.
In League Two, leaders Torquay United take on their former Blue Square Premier rivals Stevenage at the Lamex Stadium. After picking up the Manager of the Month award for August, Paul Buckle will be looking to see the Gulls return to winning ways against a team they recorded three wins and a draw against during their stint in the Conference.
One name amongst the Stevenage ranks who will be familiar to Torquay followers is that of Tim Sills, a player who played a key role in helping the Gulls return to the Football League.