Newton Abbot based Buckland Athletic remain the South West Peninsula League' s sole representative in the tournamnent and they play host to Plymouth Argyle at Homer's Heath.
The Bucks, who were founded in 1977, defeated Torquay United in the previous round and will be looking to give Argyle a run for their money.
In the other Semi-Final, Exeter City face Tiverton Town, of the Zamaretto Southern Premier League, in a repeat of the tournament's 2009 final which saw the Grecians win 2-0. Tivvy, who currently have former Torquay United favourite Kevin Hill amongst their squad, will no doubt be looking for revenge as they seek to win the competition for a 10th time.
Westinsure St Luke's Challenge Bowl Semi-Finals
Buckland Athletic vs Plymouth Argyle
Tiverton Town vs Exeter City